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Gut microbial composition identifies patients that respond to dietary FODMAP restriction

(Oslo, Norway) In a new study, scientists have developed a response index (RI) to identify which patients with irritable bowel syndrome (IBS) would benefit from a low FODMAP diet. The RI is based on 10 fecal bacterial markers included in the GA-map Dysbiosis Test.

“We were excited to see that the GA-map Dysbiosis Test was able to distinguish the responders to the diet from the non-responders”, said Jørgen Valeur, principal investigator of the study.

At least 10% of the general population is affected by Irritable bowel syndrome (IBS). The last few years, a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) has proved to be efficient in relieveling symptoms of these patients. However, the diet is very demanding and requires the exclusion of entire food groups. Not all patients respond to the diet and pre selection of patients that will benefit from the diet would be valuable. The new study, published in Digestive Disease and Sciences, showed that patients with RI from 3 to 10 were 5 times more likely to respond to the low FODMAP diet than patients with a lower RI (see the figure below).



Valeur 2017

Fig. 1 Association between Response Index (RI), based on gut microbiota composition and symptom response, as assessed as reduction in IBS-SSS in percent from baseline values.

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